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Serine racemase deletion attenuates neurodegeneration and microvascular damage in diabetic retinopathy.

Serine racemase deletion attenuates neurodegeneration and microvascular damage in diabetic retinopathy.
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Ozaki H, Inoue R, Matsushima T, Sasahara M, Hayashi A, Mori H,


Ozaki H, Inoue R, Matsushima T, Sasahara M, Hayashi A, Mori H, (click to view)

Ozaki H, Inoue R, Matsushima T, Sasahara M, Hayashi A, Mori H,

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PloS one 2018 01 0513(1) e0190864 doi 10.1371/journal.pone.0190864
Abstract

Diabetic retinopathy (DR) is a leading cause of blindness. DR is recognized as a microvascular disease and inner retinal neurodegeneration. In the course of retinal neurodegeneration, N-methyl-D-aspartate receptor (NMDAR)-mediated excitotoxicity is involved. Full activation of NMDAR requires binding of agonist glutamate and coagonist glycine or D-serine. D-Serine is produced from L-serine by serine racemase (SRR) and contributes to retinal neurodegeneration in rodent models of DR. However, the involvement of SRR in both neurodegeneration and microvascular damage in DR remains unclear. Here, we established diabetic model of SRR knockout (SRR-KO) and control wild-type (WT) mice by streptozotocin injection. Six months after the onset of diabetes, the number of survived retinal ganglion cells was higher in SRR-KO mice than that of WT mice. The reduction of thickness of inner retinal layer (IRL) was attenuated in SRR-KO mice than that of WT mice. Moreover, the number of damaged acellular capillaries was lower in SRR-KO mice than that of WT mice. Our results suggest the suppression of SRR activity may have protective effects in DR.

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