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Serologic and fecal markers to predict response to induction therapy in dogs with idiopathic inflammatory bowel disease.

Serologic and fecal markers to predict response to induction therapy in dogs with idiopathic inflammatory bowel disease.
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Otoni CC, Heilmann RM, García-Sancho M, Sainz A, Ackermann MR, Suchodolski JS, Steiner JM, Jergens AE,


Otoni CC, Heilmann RM, García-Sancho M, Sainz A, Ackermann MR, Suchodolski JS, Steiner JM, Jergens AE, (click to view)

Otoni CC, Heilmann RM, García-Sancho M, Sainz A, Ackermann MR, Suchodolski JS, Steiner JM, Jergens AE,

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Journal of veterinary internal medicine 2018 04 06() doi 10.1111/jvim.15123
Abstract
BACKGROUND
Little information is available of markers that assess the disease course in dogs with idiopathic inflammatory bowel disease (IBD).

OBJECTIVES
Evaluate relationship between disease severity and serum and fecal biomarkers in dogs with idiopathic IBD before and after treatment.

ANIMALS
Sixteen dogs with idioptahic IBD and 13 healthy dogs.

METHODS
Prospective case control study. Canine IBD activity index (CIBDAI) clinical score, serum concentrations of C-reactive protein (CRP), perinuclear antineutrophil cytoplasmic antibodies (pANCA), and serum and fecal canine calprotectin (cCP) were measured before and after 21 days of treatment.

RESULTS
Serum CRP (median 3.5 mg/L; range: 0.1-52.4 mg/L), fecal cCP (median 92.3 μg/g; range: 0.03-637.5 μg/g), and CIBDAI scores significantly increased in dogs with IBD before treatment compared with serum CRP (median 0.2 mg/L; range: 0.1-11.8 mg/L; P < .001), fecal cCP (median 0.67 μg/g; range: 0.03-27.9 μg/g; P < .001) and CIBDAI (P < .001) after treatment. No significant associations between CIBDAI scores and before or after treatment serum biomarkers. There was a significant association between fecal cCP and CIBDAI scores before treatment (rho = 0.60, P = .01). CRP and fecal cCP significantly decreased after treatment (median 3.5 mg/L v. 0.2 mg/L; P < .001 and 92.3 μg/g v. 0.67 μg/g; P = .001, respectively). CONCLUSIONS AND CLINICAL IMPORTANCE
Our data indicate that measurement of fecal cCP concentration is a useful biomarker for noninvasive evaluation of intestinal inflammation. Dogs with severe signs of GI disease more often have abnormal markers than dogs having less severe disease.

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