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Serum adiponectin and insulin secretion: a direct or inverse association?

Serum adiponectin and insulin secretion: a direct or inverse association?
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Nakamura A, Miyoshi H, Ukawa S, Nakamura K, Nakagawa T, Terauchi Y, Tamakoshi A, Atsumi T,


Nakamura A, Miyoshi H, Ukawa S, Nakamura K, Nakagawa T, Terauchi Y, Tamakoshi A, Atsumi T, (click to view)

Nakamura A, Miyoshi H, Ukawa S, Nakamura K, Nakagawa T, Terauchi Y, Tamakoshi A, Atsumi T,

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Journal of diabetes investigation 2018 02 16() doi 10.1111/jdi.12821
Abstract

We investigated the association between serum high molecular weight (HMW) adiponectin and insulin secretion in a population-based study, with or without adjustment for insulin sensitivity. A total of 488 participants (263 women) were included in the present study. Insulin secretion was estimated using the homeostasis model assessment of beta-cell function (HOMA-β%) ± adjustment for insulin resistance (IR) using the disposition index (DI). Multivariate analysis revealed that HMW adiponectin was significantly and inversely associated with HOMA-β% (partial regression coefficient: -0.19, 95% confidence interval (CI): (-0.28, -0.10), p < 0.0001). However, HMW adiponectin was significantly and positively associated with DI (partial regression coefficient: 0.15, 95% CI: (0.06, 0.24), p = 0.0016). Our study revealed that a positive association between HMW adiponectin levels and insulin secretion evaluated using an index incorporating adjustment for IR was identified, and vice versa using an index that did not adjust for IR. This article is protected by copyright. All rights reserved.

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