Non-alcoholic fatty liver disease (NAFLD) is now regarded as the hepatic manifestation of metabolic syndrome (MetS). Recent research has suggested that serum creatinine (SCr) may be an indicator of MetS and its related diseases. We aimed to investigate the association between serum creatinine and NAFLD in Chinese adults.
A cross-sectional sample of 8862 subjects aged 40 yrs or older (40-73 yrs) from China were analyzed in this study. The anthropometric measurements, laboratory tests, and hepatic ultrasonography were conducted. NAFLD presence was defined by hepatic ultrasound in the absence of other liver diseases.
NAFLD subjects had higher serum creatinine than those without NAFLD (66.8 µmol/L vs. 65.6 µmol/L, p<0.001). Moreover, Scr levels were correlated with alanine aminotransferase (β=0.099, p<0.001), aspartate aminotransferase (β=0.135, p<0.001), γ-glutamyltransferase (β=0.039, p<0.001) and insulin resistance (β=0.027, p=0.014) after adjusted for potential covariates. In the multivariable-adjusted logistic regression analyses, compared to the 1 SCr quintile, the odds ratio for NAFLD was 1.35 (95% CI 1.14-1.60, p<0.001) for the 5 quintile after adjusting multiple measured confounders.
Serum creatinine concentration is independently associated with NAFLD in a middle aged and older Chinese population. Elevated SCr levels, even within normal ranges, were associated with higher risk of NAFLD. This article is protected by copyright. All rights reserved.

This article is protected by copyright. All rights reserved.