This study states that In spite of the fact that tracheobronchial stenosis (TBS) is a generally remarkable clinical indication of granulomatosis with polyangiitis (GPA)1,2, it can cause extreme aviation route impediment, prompting lethal consequences1,2,3,4,5.
A 43-year-elderly person with biopsy-demonstrated GPA gave abrupt extreme chest torment and dyspnea with no different indications like hack or fever. She had a 7-year history of repetitive orbital sores, sinusitis, and septal hole, controlled with 10 mg/day of prednisolone (PSL), tacrolimus, azathioprine, and rituximab. Her breathing sound was reduced in the left lung field. C-responsive protein and proteinase 3–antineutrophil cytoplasmic antibodies were negative. Chest radiography showed critical mediastinal shift because of atelectasis. Processed tomography exhibited total deterrent of the left fundamental stem bronchus (MSB; Figure 1–A2 to 1–A4). Bronchoscopy affirmed that the bronchial lumen was hindered with aggravated and necrotic tissue and dying. Cytology and culture of bronchoalveolar lavage liquid were negative. She was treated with beat methylprednisolone followed by 50 mg/day of PSL. On Day 5, the MSB check was assuaged with no mechanical treatments. Followup chest imaging in 2 months showed returning of the blocked bronchial lumen.
Reference link- https://www.jrheum.org/content/47/8/1293