An international study of more than 3.2 million people with severe mental illness reveals a substantially increased risk for developing cardiovascular disease compared to the general population.

Led by King’s College London, the research shows that people with severe mental illness (SMI), including schizophrenia, bipolar disorder and major depression, have a 53 per cent higher risk for having cardiovascular disease than healthy controls, with a 78 per cent higher risk of developing cardiovascular disease over the longer term. Their risk of dying from the disease was also 85 per cent higher than people of a similar age in the general population.

Published online in World Psychiatry, these findings highlight the importance of regularly screening SMI patients for cardiovascular risk and also point towards a number of potentially modifiable risk factors.

It is well documented that people with SMI die 10 to 15 years earlier than the general population, largely due to cardiovascular disease, including heart disease, heart attack and stroke.


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This new study is the largest ever meta-analysis of SMI and cardiovascular disease, including over 3.2 million patients and more than 113 million people from the general population. The researchers examined 92 studies across four continents and 16 different countries, including the US, UK, France, Australia and Sweden.10 per cent of people with SMI had cardiovascular disease, with rates slightly higher in schizophrenia (11.8 per cent) and depression (11.7 per cent) than bipolar disorder (8.4 per cent), with a substantially increased risk for developing cardiovascular disease over time.

The researchers identified some important factors which increase risk for cardiovascular disease, including antipsychotic use and higher body mass index. Based on these results, it is crucial that clinicians where possible choose antipsychotics with lower side effects related to weight gain, high blood pressure and glucose abnormalities.

Click here to read the full press release.