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Significant reductions in alcohol use after Hepatitis C treatment: Results from the French ANRS CO13-HEPAVIH cohort.

Significant reductions in alcohol use after Hepatitis C treatment: Results from the French ANRS CO13-HEPAVIH cohort.
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Knight R, Roux P, Vilotitch A, Marcellin F, Rosenthal E, Esterle L, Boué F, Rey D, Piroth L, Dominguez S, Sogni P, Salmon-Ceron D, Spire B, Carrieri MP, ,


Knight R, Roux P, Vilotitch A, Marcellin F, Rosenthal E, Esterle L, Boué F, Rey D, Piroth L, Dominguez S, Sogni P, Salmon-Ceron D, Spire B, Carrieri MP, , (click to view)

Knight R, Roux P, Vilotitch A, Marcellin F, Rosenthal E, Esterle L, Boué F, Rey D, Piroth L, Dominguez S, Sogni P, Salmon-Ceron D, Spire B, Carrieri MP, ,

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Addiction (Abingdon, England) 2017 04 21() doi 10.1111/add.13851

Abstract
BACKGROUND AND AIMS
Few data exist on changes to substance use patterns before and after hepatitis C virus (HCV) treatment. We used longitudinal data of HIV-HCV co-infected individuals to examine whether receiving Peg-interferon (Peg-IFN)-based therapy irrespective of HCV clearance could modify tobacco, cannabis and alcohol use.

DESIGN
A prospective cohort of HIV-HCV co-infected individuals was enrolled from 2006. Participants’ clinical data were retrieved from medical records and socio-demographic and behavioral characteristics were collected by yearly self-administered questionnaires.

SETTING
Data were collected across seventeen hospitals in France.

PARTICIPANTS
All HIV-HCV co-infected patients who initiated HCV treatment during follow-up and answered items regarding substance use in at least one yearly questionnaire (258 patients, 671 visits).

INTERVENTION
HCV treatment consisted of Peg-IFN based regimens.

MEASUREMENTS
Four time-varying outcomes: hazardous alcohol use (AUDIT-C > 3/4 for women/men), number of alcohol units/month, binge drinking, cannabis and tobacco use. Mixed models assessed the effect of HCV treatment status (not yet treated, treated and HCV-cleared, treated and HCV-chronic) on each outcome.

FINDINGS
A significant decrease (over 60% reduction) in both hazardous alcohol use and binge drinking and a reduction of 10 alcohol units/month were observed after HCV treatment (whatever the outcome). No significant effect of HCV treatment status was found on tobacco use and regular cannabis use but HCV ‘clearers’ reported less non-regular use of cannabis.

CONCLUSIONS
Hepatitis C virus (HCV) treatment appears to help HIV-HCV co-infected patients reduce alcohol use.

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