Advertisement

 

 

Simulation of head and neck cancer oxygenation and doubling time in a 4D cellular model with angiogenesis.

Simulation of head and neck cancer oxygenation and doubling time in a 4D cellular model with angiogenesis.
Author Information (click to view)

Forster JC, Douglass MJJ, Harriss-Phillips WM, Bezak E,


Forster JC, Douglass MJJ, Harriss-Phillips WM, Bezak E, (click to view)

Forster JC, Douglass MJJ, Harriss-Phillips WM, Bezak E,

Advertisement
Share on FacebookTweet about this on TwitterShare on LinkedIn

Scientific reports 2017 09 087(1) 11037 doi 10.1038/s41598-017-11444-1
Abstract

Tumor oxygenation has been correlated with treatment outcome for radiotherapy. In this work, the dependence of tumor oxygenation on tumor vascularity and blood oxygenation was determined quantitatively in a 4D stochastic computational model of head and neck squamous cell carcinoma (HNSCC) tumor growth and angiogenesis. Additionally, the impacts of the tumor oxygenation and the cancer stem cell (CSC) symmetric division probability on the tumor volume doubling time and the proportion of CSCs in the tumor were also quantified. Clinically relevant vascularities and blood oxygenations for HNSCC yielded tumor oxygenations in agreement with clinical data for HNSCC. The doubling time varied by a factor of 3 from well oxygenated tumors to the most severely hypoxic tumors of HNSCC. To obtain the doubling times and CSC proportions clinically observed in HNSCC, the model predicts a CSC symmetric division probability of approximately 2% before treatment. To obtain the doubling times clinically observed during treatment when accelerated repopulation is occurring, the model predicts a CSC symmetric division probability of approximately 50%, which also results in CSC proportions of 30-35% during this time.

Submit a Comment

Your email address will not be published. Required fields are marked *

2 × 5 =

[ HIDE/SHOW ]