Clinical & experimental ophthalmology 2017 05 04() doi 10.1111/ceo.12974
Asian Indians are the fastest growing migration groups in the world. Studies evaluating the impact of migration on disease outcomes in this population are rare.
We describe the methodology of the Singapore Indian Eye Study-2 (SINDI-2) aimed to evaluate the impact of migration status on diabetic retinopathy (DR) and other major age-related eye diseases in Asian Indians living in an urban environment.
Population-based cohort study PARTICIPANTS: 2200 adults who participated in baseline SINDI (2007-09, mean age [range] = 57.8 [42.7-84.1] years) and SINDI-2 (2013-15, 56.5 [48.4-90.2] years).
Participants were classified as "first-generation" if they were Indian residents born outside of Singapore and as "second-generation" immigrants (59.7% in SINDI vs. 63.6% in SINDI-2) if they were born in Singapore.
MAIN OUTCOME MEASURES
Response rate, participant characteristics and prevalence of systemic diseases stratified by migration status.
Of the 2914 eligible SINDI participants invited to participate, 2200 participated in SINDI-2 (response rate of 75.2%). In both SINDI and SINDI-2, compared to first-generation, second-generation immigrants were younger, less likely to have income <1000 SGD, had lower levels of pulse pressure, higher levels of high-density lipoprotein cholesterol, had lower prevalence of hypertension, and chronic kidney disease (CKD); had higher prevalence of current smoking, and obesity (all p < 0.05). CONCLUSIONS AND RELEVANCE
In both SINDI and SINDI-2, second-generation immigrants had lower prevalence of cardiovascular risk factors except smoking and obesity compared to first-generation. The final report will confirm if these differences between generations are evident with regards to eye diseases.