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Sodium excretion is higher in patients with rheumatoid arthritis than in matched controls.

Sodium excretion is higher in patients with rheumatoid arthritis than in matched controls.
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Marouen S, du Cailar G, Audo R, Lukas C, Vial G, Tournadre A, Barrat E, Ribstein J, Combe B, Morel J, Daien CI,


Marouen S, du Cailar G, Audo R, Lukas C, Vial G, Tournadre A, Barrat E, Ribstein J, Combe B, Morel J, Daien CI, (click to view)

Marouen S, du Cailar G, Audo R, Lukas C, Vial G, Tournadre A, Barrat E, Ribstein J, Combe B, Morel J, Daien CI,

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PloS one 2017 10 1312(10) e0186157 doi 10.1371/journal.pone.0186157
Abstract
OBJECTIVE
It was shown that sodium can promote auto-immunity through the activation of the Th17 pathway. We aimed to compare sodium intake in patients with rheumatoid arthritis (RA) vs. matched controls.

METHODS
This case-control study included 24 patients with RA at diagnosis and 24 controls matched by age, gender and body mass index. Sodium intake was evaluated by 24-hr urinary sodium excretion.

RESULTS
Sodium excretion was greater for patients with early RA (2,849±1,350 vs. 2,182±751.7mg/day, p = 0.039) than controls. This difference remained significant after adjustment for smoking and the use of anti-hypertensive and nonsteroidal anti-inflammatory drugs (p = 0.043). Patients with radiographic erosion at the time of diagnosis had a higher sodium excretion than those without (p = 0.028).

CONCLUSION
Patients with early RA showed increased sodium excretion which may have contributed to autoimmunity.

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