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Soluble membrane attack complex in the blood and cerebrospinal fluid of HIV-infected individuals, relationship to HIV RNA, and comparison with HIV negatives.

Soluble membrane attack complex in the blood and cerebrospinal fluid of HIV-infected individuals, relationship to HIV RNA, and comparison with HIV negatives.
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Anderson AM, Schein TN, Kalapila A, Lai L, Waldrop-Valverde D, Moore RC, Franklin D, Letendre SL, Barnum SR,


Anderson AM, Schein TN, Kalapila A, Lai L, Waldrop-Valverde D, Moore RC, Franklin D, Letendre SL, Barnum SR, (click to view)

Anderson AM, Schein TN, Kalapila A, Lai L, Waldrop-Valverde D, Moore RC, Franklin D, Letendre SL, Barnum SR,

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Journal of neuroimmunology 2017 07 23311() 35-39 pii 10.1016/j.jneuroim.2017.07.014

Abstract

The soluble membrane attack complex (sMAC) represents the terminal product of the complement cascade. We enrolled 47 HIV+ adults (12 of whom underwent a second visit at least 24weeks after starting therapy) as well as 11 HIV negative controls. At baseline, cerebrospinal fluid (CSF) sMAC was detectable in 27.7% of HIV+ individuals. CSF sMAC correlated with CSF HIV RNA levels and was more likely to be detectable in HIV+ individuals on cART compared to HIV negative controls. In HIV+ participants, there were negative association trends between sMAC and neurocognitive performance but these did not reach statistical significance.

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