Advertisement

 

 

Spatiotemporal and demographic history of the HIV-1 circulating recombinant form CRF31_BC in Brazil.

Spatiotemporal and demographic history of the HIV-1 circulating recombinant form CRF31_BC in Brazil.
Author Information (click to view)

Fritsch HM, Almeida SEM, Pinto AR, Gräf T,


Fritsch HM, Almeida SEM, Pinto AR, Gräf T, (click to view)

Fritsch HM, Almeida SEM, Pinto AR, Gräf T,

Advertisement

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2018 03 27() pii 10.1016/j.meegid.2018.03.024

Abstract

CRF31_BC is an HIVs-1 recombinant form very prevalent in the southernmost capital city of Brazil, Porto Alegre. Recent studies have been describing a growing number of cases of infection by CRF31_BC in other Brazilian cities and countries, suggesting a process of expansion of this strain. Aiming to describe the city of origin, dispersion routes and demographic history of CRF31_BC, this study analyzed all HIV-1 CRF31_BC and Brazilian BC mosaic publicly available sequences. CRF31_BC classification was performed by bootscanning and tree reconstruction methods. Bayesian phylogeographic and phylodynamic model approaches were used to reconstruct the spatiotemporal and demographic history of 95 sequences identified as CRF31_BC-like. Porto Alegre was estimated to be the origin and center of the dispersion of the CRF31_BC for most of the analyzed locations. However, some viral transitions independent from Porto Alegre were observed in other cities from the Rio Grande do Sul state and also in other Brazilian states. The estimated CRF31_BC epidemic growth rate was similar to subtype C and B in Brazil. Our findings suggest that CRF31_BC, although mostly prevalent in south region, is circulating nation-wide with some localities presenting autochthonous transmissions.

Submit a Comment

Your email address will not be published. Required fields are marked *

one × two =

[ HIDE/SHOW ]