For a study, researchers sought to determine if past statin medication led to fewer AHF episodes and better AHF survival in individuals with acute coronary syndrome (ACS) as their first sign of ASCVD. The information came from the International Survey of Acute Coronary Syndromes Archives. The research included 14,542 Caucasian individuals who presented with ACS but had no prior ASCVD episodes. Statin users were compared to nonusers using inverse probability weighting models before the index event. The estimates were compared using an interaction test on the log scale. The primary outcome measures were the incidence of AHF according to Killip class and the rate of 30-day all-cause death in AHF patients. 

Previous statin medication was linked with a significantly lower rate of AHF on admission (4.3% absolute risk reduction; risk ratio [RR]: 0.72; 95% CI: 0.62-0.83) regardless of age (interaction P=0.27) or gender (interaction P=0.22). Furthermore, prior statin medication indicated a decreased risk of 30-day death in the sample of patients admitted with AHF (5.2% absolute risk reduction; RR: 0.71; 95% CI: 0.50-0.99). Previous statin medication was related to a lower incidence of AHF and increased survival from AHF in persons who present with ACS as the initial manifestation of ASCVD.