Baseline risk factors associated with frequent STIs included having an STI at baseline, a higher number of sexual partners within a 2-month period, and drug use, according to findings published in AIDS. Jean-Michel Molina, MD, and colleagues offered men who have sex with men and transgender women up to 4 years of PrEP and screened for bacterial STIs at baseline and every 6 months. During a median follow-up of 23 months, bacterial STI incidence rates were 75, 33, 13, 32, and 30 per 100 person-years (PY) for all STIs, rectal STIs, syphilis, gonorrhea, and chlamydia, respectively. STI incidence significantly increased from the first to fourth year (55 vs 90 per 100 PY), and 39% of participants presented with more than one bacterial STI, accounting for 86% of all STIs. Baseline factors associated with recurrent STIs in a multivariate analysis were STI at baseline, more than eight sexual partners in the preceding 2 months, and gamma hydroxybutyrate use.