Listeria monocytogenes is a well borne pathogen that is responsible for Listeriosis. It is a maternal- neonatal infection. Researchers executed a nationwide analysis of features associated with neonatal Listeriosis. All neonates born alive from mothers were analyzed with microbiology-proven maternal, neonatal Listeriosis from November 2009 to December 2017. Analyzation of the neonatal outcome at discharge, presentation, and predictors of severe presentation and outcome was done. Examinations stated that out of 189 infants; 133 of 189 (70%) had abnormal clinical status at birth, including acute respiratory distress in 106 of 189 (56%)., 132 of 189 (70%) infants who developed early-onset Listeriosis, and 12 of 189 (6%) who developed late-onset Listeriosis; all presented with acute meningitis. There were 17 of 189 (9%) infants who had significant adverse outcomes: 3%, (5 of 189) death; 6% (12 of 189), severe brain injury; and 2% (3 of 189), severe bronchopulmonary dysplasia. Fifteen of 17 infants were born under 34 weeks of gestation (P<.0001 vs infants born ≥34 weeks of gestation). Maternal antimicrobial treatment greater than or equal to 1 day before delivery was related with a relevant decrease in presentation severity for the infant, resulting in fewer inotropic drugs, fluid resuscitation, and mechanical ventilation requirement (odds ratio, 0.23; 95% confidence interval, 0.09–0.51; P<.0001). It was found that anti-Natal maternal antimicrobial treatment is related to reduced neonatal listeriosis severity will stop neonatal outcome coming out to be better than reported earlier, and its major determinant was found to be gestational age at birth.
Link:academic.oup.com/cid/article-abstract/74/1/8/6238637?redirectedFrom=fulltext
