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Subcutaneous injection of H2 is a novel effective treatment for type 2 diabetes.

Subcutaneous injection of H2 is a novel effective treatment for type 2 diabetes.
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Zhang X, Liu J, Jin K, Xu H, Wang C, Zhang Z, Kong M, Zhang Z, Wang Q, Wang F,


Zhang X, Liu J, Jin K, Xu H, Wang C, Zhang Z, Kong M, Zhang Z, Wang Q, Wang F, (click to view)

Zhang X, Liu J, Jin K, Xu H, Wang C, Zhang Z, Kong M, Zhang Z, Wang Q, Wang F,

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Journal of diabetes investigation 2017 04 08() doi 10.1111/jdi.12674
Abstract
AIMS/INTRODUCTION
In previous studies H2 administration has clearly shown effectiveness in inhibiting diabetes. Here, we evaluated whether subcutaneous injection of H2 shows enhanced efficacy against type 2 diabetes mellitus (T2DM) induced in mice by a high-fat diet and low dose streptozotocin (STZ) treatment.

MATERIAL AND METHODS
H2 was injected subcutaneously at a dose of 1ml/mouse/week for four weeks. T2DM associated parameters were then evaluated to determine the effectiveness of subcutaneous H2 administration.

RESULTS
The body weight of H2 -treated mice did not change over the course of the experiment. Compared to the untreated control animals, glucose, insulin, low-density lipoprotein (LDL) and triglyceride (TG) levels in serum were significantly lower in treated mice, while high-density lipoprotein cholesterol (HDL) in the serum was significantly higher. Glucose tolerance and insulin sensitivity were both improved in H2 -treated mice. Diabetic nephropathy (DN) analysis showed significant reductions in urine volume, urinary total protein and β2 microglobulin, kidney/body weight ratio and kidney fibrosis associated with subcutaneous injection of H2 .

CONCLUSIONS
Subcutaneous injection of H2 significantly improves T2DM and DN related outcomes in a mouse model, supporting further consideration of subcutaneous injection as a novel and effective route of clinical H2 administration. This article is protected by copyright. All rights reserved.

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