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The following is a summary of “Allergic Rhinitis is Associated with Increased Suicidality: A Systematic Review and Meta-Analysis,” published in the May 2025 issue of Clinical Reviews in Allergy & Immunology by Høj et al.
Allergic rhinitis (AR), an inflammatory condition, has shown arising links to suicidality, an association that warrants further investigation compared to the well-studied relationship between other atopic diseases and mental health in psychiatry.
Researchers conducted a retrospective study to examine the association between AR and the risks of suicidal ideation, suicide attempts, and suicide death.
They followed PRISMA guidelines to conduct a systematic search across PubMed, Embase, PsycINFO, Cochrane databases, Web of Science, Scopus, CINAHL, and Google Scholar. A total of 590 studies were screened, and 9 cross-sectional studies involving 1,604,962 participants met the inclusion criteria. Data related to suicidal ideation, suicide attempts, and suicide death were analyzed using random-effects meta-analyses. Odds ratios (ORs) with 95% CIs were calculated. The Joanna Briggs Institute Critical Appraisal Checklist was used to evaluate the risk of bias. The certainty of evidence was rated using the GRADE framework.
The results showed that AR was not significantly linked to suicidal ideation (OR: 1.12, 95% CI: 0.97–1.30; 1,101,819 participants from 7 studies). An increased risk was observed for suicide attempts among individuals with AR (OR: 1.25, 95% CI: 1.00–1.57; 1,554,297 participants from 5 studies). The risk of suicide death was also higher in this group (OR: 1.65, 95% CI: 1.46–1.86; 478,244 participants from 2 studies).
Investigators concluded that AR was linked with a higher risk of suicide attempts and death, though causality could not be determined due to the cross-sectional design of the included studies.
Source: link.springer.com/article/10.1007/s12016-025-09061-2
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