For a study, researchers sought to characterize the diagnosis and therapy of the uncommon illness, and a comprehensive study of mixed epithelial stromal tumors of the seminal vesicle (SV) was conducted.

Through September 6, 2021, PubMed/MEDLINE was searched for papers that addressed the terms “seminal vesicle mixed epithelial stromal tumor” OR “seminal vesicle cystadenoma.” Articles met the criteria for eligibility if they were in English, available through the university’s library services, and the abstract agreed with the publication’s content. To find more pertinent papers, reference lists of included articles were examined.

There were found to be 66 papers in total, of which 34 (N = 36 patients) were included. Lower urinary tract symptoms (33%, 12/36), dysuria (22%, 8/36), lower abdomen discomfort (17%, 6/36), and hematuria (17%, 6/36) were the most prevalent presenting symptoms. Eight instances of incidental SV tumors, or 23% of the total, were asymptomatic. 47% of the patients (17/36) had a biopsy, of which 53% (9/17) revealed benign findings, 29% (5/17) yielded inconclusive results, and 18% (3/17) revealed an SV cystadenoma. Open surgery was used the most frequently (57%, 20/35), followed by laparoscopic surgery (26%, 9/35) and robotic surgery (17%, 6/35). 94% of the SV tumors, or 34 out of 36, were low-grade. Two patients (13%, 2/15) had tumor recurrence during long-term follow-up, which was documented for 15 patients.

The high proportion of SV tumor inconclusive biopsies raised doubts about the value of regular biopsies. Symptoms were typically relieved, and a precise pathologic diagnosis was confirmed by surgical removal. Cross-sectional imaging of the pelvis should be performed to monitor patients for tumor recurrence after tumor excision.