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Synergistic Inhibitory Effect of GQDs-Tramiprosate covalent binding on amyloid Aggregation.

Synergistic Inhibitory Effect of GQDs-Tramiprosate covalent binding on amyloid Aggregation.
Author Information (click to view)

Liu Y, Xu LP, Wang Q, Yang B, Zhang X,


Liu Y, Xu LP, Wang Q, Yang B, Zhang X, (click to view)

Liu Y, Xu LP, Wang Q, Yang B, Zhang X,

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ACS chemical neuroscience 2017 12 15() doi 10.1021/acschemneuro.7b00439
Abstract

Inhibiting the amyloid aggregation is considered to be an effective strategy to explore possible treatment of amyloid-related diseases including Alzheimer’s disease, Parkinson’s disease, and type II diabetes. Herein, a new high-efficiency and low-cytotoxicity Aβ aggregation inhibitors, GQD-T was designed through the combination of two Aβ inhibitors graphene quantum dots (GQDs) and tramiprosate. GQD-T showed the capability of efficiently inhibiting the aggregation of Aβ peptides and rescuing Aβ-induced cytotoxicity due to the synergistic effect of the GQDs and tramiprosate. In addition, the GQD-T has the characteristics of low toxicity and great biocompatibility. It is believed that GQD-T may be a potential candidate of Alzheimer’s drug and this work provides a new strategy for exploring Aβ peptide aggregation inhibitors.

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