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Synovial fluid biomarkers: association with chronic rotator cuff tear severity and pain.

Synovial fluid biomarkers: association with chronic rotator cuff tear severity and pain.
Author Information (click to view)

Shih CA, Wu KC, Shao CJ, Chern TC, Su WR, Wu PT, Jou IM,


Shih CA, Wu KC, Shao CJ, Chern TC, Su WR, Wu PT, Jou IM, (click to view)

Shih CA, Wu KC, Shao CJ, Chern TC, Su WR, Wu PT, Jou IM,

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Journal of shoulder and elbow surgery 2017 11 21() pii S1058-2746(17)30599-2
Abstract
BACKGROUND
We tested the hypothesis that biomarkers in the synovial fluid of the glenohumeral (shoulder) joint are correlated with visual analog scale (VAS) scores, functional scores, and ultrasound findings of chronic rotator cuff tear (RCT) severity.

METHODS
We measured biomarkers in shoulder joint synovial fluid of 42 patients with partial-thickness (21), nonmassive full-thickness (10), and massive full-thickness (11) RCTs. Pain duration, tear severity, and VAS and functional scores were compared with interleukin (IL) 1β, IL-6, matrix metalloproteinase (MMP) 1, and MMP-13 levels.

RESULTS
Both MMP-1 and MMP-13 levels were significantly highest in the massive full-thickness group. MMP-13 levels were significantly different between groups, but proinflammatory cytokine IL-1β and IL-6 levels were not. However, IL-1β levels were significantly positively correlated with VAS (r = 0.66; P <.01) and functional scores (r = 0.61; P <.01), but IL-6, MMP-1, and MMP-13 levels were not. CONCLUSIONS
IL-1β levels in shoulder synovial fluid correlated positively with shoulder pain and functional scores in patients with chronic RCTs. Both MMP-1 and MMP-13 levels were altered and increased with cuff tear severity.

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