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Synthesis and evaluation of coumarin derivatives against human lung cancer cell lines.

Synthesis and evaluation of coumarin derivatives against human lung cancer cell lines.
Author Information (click to view)

Weng KG, Yuan YL,


Weng KG, Yuan YL, (click to view)

Weng KG, Yuan YL,

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Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2017 09 1250(11) e6455 pii S0100-879X2017001100603
Abstract

Series of novel coumarin derivatives [I (a-d) and II (a-d)] were successfully synthesized and their structures were determined based on infrared 1H-nuclear magnetic resonance (NMR), HRMS, and single crystal X-ray crystallography. Additionally, the new synthesized compounds were evaluated to identify the molecular characteristics that contribute to their cytotoxicity, which was tested against SK-LU-1, SPC-A-1 and 95D human lung cancer cell lines, using the MTT assay. The results of this study showed that compounds Ic, Id, IIc, and IId exhibited an efficient percentage of inhibition of cell proliferation.

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