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Synthesis of HIV-1 capsid protein assembly inhibitor (CAP-1) and its analogues based on a biomass approach.

Synthesis of HIV-1 capsid protein assembly inhibitor (CAP-1) and its analogues based on a biomass approach.
Author Information (click to view)

Romashov LV, Ananikov VP,


Romashov LV, Ananikov VP, (click to view)

Romashov LV, Ananikov VP,

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Organic & biomolecular chemistry 2016 09 3014(45) 10593-10598

Abstract

A biomass-derived platform chemical was utilized to access a demanded pharmaceutical substance with anti-HIV activity (HIV, human immunodeficiency virus) and a variety of structural analogues. Step economy in the synthesis of the drug core (single stage from cellulose) is studied including flexible variability of four structural units. The first synthesis and X-ray structure of the inhibitor of HIV-1 capsid protein assembly (CAP-1) is described.

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