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T Regulatory Cells in Bone Remodelling.

T Regulatory Cells in Bone Remodelling.
Author Information (click to view)

Bozec A, Zaiss MM,


Bozec A, Zaiss MM, (click to view)

Bozec A, Zaiss MM,

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Current osteoporosis reports 2017 04 21() doi 10.1007/s11914-017-0356-1
Abstract
PURPOSE OF THE REVIEW
In this review, we present the role of regulatory T (Treg) cells in bone remodelling and bone-related disease such as osteoporosis or inflammatory bone loss. We also discuss the cellular and molecular mechanism how Treg cells regulate osteoclastogenesis.

RECENT FINDINGS
Treg cells could regulate osteoclastogenesis by secreting TGF-β and IL-10 as well as IL-4 cytokines. Moreover, Treg cells can additionally regulate osteoclast differentiation, in a cell-to-cell contact via the cytotoxic T lymphocyte antigen (CTLA-4). The latter induces the apoptosis of osteoclasts dependent on CD80/86 in vitro and in vivo. Treg cells mediate immunosuppressive function that controls undesired immune reactions, such as autoimmunity. Recently, Treg cells have been shown to influence non-immunological processes, such as bone homeostasis. Accumulated evidences have demonstrated that Treg cells can suppress osteoclast differentiation in vitro and in vivo.

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