The Clinical Effectiveness and patient experience of transanal irrigation (TAI) in children with constipation or fecal incontinence were investigated. Researchers carried out a combined retrospective and cross-sectional study which included pediatric patients who used a Navina TAI system. They retroactively collected baseline characteristics and treatment success data at first and sixth-month follow-up (FU). Treatment success was defined as the bowel movement at least 3 times per week and having less than 1 episode of accidental bowel leakage per week. Using a verified set of questions, they cross-sectionally assessed health-related quality of life (HRQoL), treatment adherence, treatment satisfaction (Treatment Satisfaction Questionnaire for Medication [TSQM]), illness perceptions, medication beliefs, and patient empowerment. Investigators included 34 patients (median age at start TAI: 11 years old[range,6-18], 32 in the retrospective review, and 26 in the cross-sectional survey (median of 3 years after initiation). Majority of the patients were diagnosed with functional constipation (n=26;76%) or neurogenic bowel disorder(n=6;18%). Treatment success rates remarkably enhanced at each FU compared with baseline (baseline:4/25 [16%]; 1-month FU;12/16 [75%], P=0.008; 6-month FU; 11/18 [61%] P=0.016; cross-sectional FU:13/26 [50%], P=0.008). HRQoL scores were at the top (PedsQL median, 73 [IQR, 54–85]). Adherence (defined as Medication Adherence Report Scale [MARS]≥23) was low (36%), whereas TSQM efficacy scores were high (median, 69 [IQR, 47–86]). Most of the children (61%) recorded increased independence since TAI treatment. Patient empowerment (GYPES) levels were identical to those reported in children with other chronic conditions.TAI with a Navina system is an efficient bowel management system for children with uncompromising constipation or fecal incontinence.