Despite the fact that today’s cornerstone asthma treatments target airway constriction and lung inflammation, approximately 50% of asthmatic patients do not obtain adequate disease control. There is an undeniable need for innovative treatment methods and pharmacological targets. A recent study has found that some taste receptors (especially those involved in bitter taste transduction) are expressed in lung tissue, which was previously unknown. Bitter taste receptors are present in a variety of cell types in the lungs and are implicated in ciliary beating, muscle relaxation, and/or the regulation of inflammatory mediator synthesis. This study presents an overview of recent studies on the involvement of bitter taste receptors in asthma experimental models and in asthmatics.
Based on existing evidence, bitter taste receptor agonists may have therapeutic promise in chronic obstructive airway disorders such as asthma.