Advertisement

 

 

Taurine and tea polyphenols combination ameliorate nonalcoholic steatohepatitis in rats.

Taurine and tea polyphenols combination ameliorate nonalcoholic steatohepatitis in rats.
Author Information (click to view)

Zhu W, Chen S, Chen R, Peng Z, Wan J, Wu B,


Zhu W, Chen S, Chen R, Peng Z, Wan J, Wu B, (click to view)

Zhu W, Chen S, Chen R, Peng Z, Wan J, Wu B,

Advertisement
Share on FacebookTweet about this on TwitterShare on LinkedIn

BMC complementary and alternative medicine 2017 09 0817(1) 455 doi 10.1186/s12906-017-1961-3
Abstract
BACKGROUND
Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease, for which there is currently no safe and effective drug for therapy. In this study, we explored the effects of taurine, tea polyphenols (TPs), or a combination thereof, on NASH rats.

METHODS
Rats were divided into a normal group, a high-fat diet induced model group and a treatment group (including taurine, TPs, or taurine + TPs treatment for 8 weeks). Twelve weeks later, all rats were sacrificed, and serum transaminase, lipid and lipopolysaccharide levels and hepatic oxidative stress levels were determined. Histological changes were evaluated.

RESULTS
In NASH rats, hepatocyte damage, lipid disturbance, oxidative stress and elevated lipopolysaccharide levels were confirmed. Taurine treatment alleviated hepatocyte damage and oxidative stress. TPs treatment improved lipid metabolism and increased hepatic antioxidant activity. The therapeutic effects of taurine + TPs treatment on hepatocyte damage, lipid disturbance, and oxidative stress were superior to those of taurine and TPs treatment, respectively. Taurine, TPs and their combination all decreased serum lipopolysaccharide levels in NASH rats, but the combination of the compounds caused these levels to decrease more significantly than taurine or TPs treatment alone.

CONCLUSION
Taurine combined with TPs treatment could relieve NASH by alleviating hepatocyte damage, decreasing oxidative stress and improving lipid metabolism and gut flora disturbance partly. Taurine and TPs combination may act as a new effective medicine for treating NASH patients.

Submit a Comment

Your email address will not be published. Required fields are marked *

5 + one =

[ HIDE/SHOW ]