TCT 2012: Denervation Treatment Beneficial for Refractory PAH


The Particulars: Research has shown that pulmonary vein ablation can be used successfully to treat atrial fibrillation. Catheter-based pulmonary artery denervation is an experimental procedure similar to renal sympathetic nerve ablation, a treatment that has been shown to reduce blood pressure in people with refractory hypertension. The denervation procedure has not been studied in treating pulmonary artery hypertension (PAH).

Data Breakdown: For a study, patients who were unresponsive to a combination of PAH medications without a positive adenosine test were split into two groups. The first underwent denervation, in which the nerve bundle around the pulmonary artery was ablated. The second group (controls) continued medication. Those who underwent denervation experienced average decreases in pulmonary artery pressure of 37 mm Hg to 23 mm Hg. Controls experienced no change in their pulmonary artery pressure.

Take Home Pearl: Catheter-based denervation appears to be a viable treatment option for patients with refractory PAH.


  1. Thanks, please send me more details about the procedure , contraindications, who perform it, complications
    i know that the defect is at the level of pulmonary vascular bed so how this will lower the PAP

  2. It is the first time I heard about denervation as a Option to refratary HAP. Please send me more detail. Is is done by suregry, catheter.

    • The only doctor performing the procedure is Shao liang Chen, a cardiac surgeon in Nanjing China. My dad and I went in September. It was so perfect. His post procedure results were 50% reduction in pulmonary pressure. For most patients it has been 33%
      I’m happy to give you all the details, if you’d like to contact me.
      There are preclusions. Age limit is 82.
      At this time you can receive the procedure. When it goes in clinical trials, there will be restrictions.


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