Investigators sought to assess the impact of telerehabilitation in patients with MS during the isolation period of the COVID-19 pandemic. They conducted a retrospective analysis using medical records from adults with MS and employed the use of scores from the Modified Fatigue Impact Scale (MFIS), the Expanded Disability Status Scale (EDSS), and the MS Quality of Life-54 (MSQOL-54). The Wilcoxon Signed Test Station was used to confirm the differences between the moments of pre-intervention and post-intervention. In most cases, MFIS scores at pre-intervention were higher than the post-intervention scores, and the MSQOL-54 scale scores were lower in the pre-intervention period compared with the post-intervention period. Application of the Spearman correlation analysis validated the degree of the relationship between the variables of the scale results and age, sex, and EDSS score. The EDSS also demonstrated a good relationship with both the MFIS and the MSQOL-54. According to the study team, the results demonstrate that telerehabilitation provided during the pandemic had a positive impact on fatigue and QOL among patients with MS.