Chemistry & biodiversity 2018 03 22() doi 10.1002/cbdv.201700560
Three new compounds (1-3), including two euphane type triterpenes, 25,26,27-trinor-3α-hydroxy-24-dimethoxyeuphane (1), and euphane-24β-hydroperoxy-8,25-diene-3β-ol (2), and an ent-atisine diterpene, ent-atisane-3α, 16α, 17-triol (3) were isolated from an acetone extract of the stems of Euphorbia antiquorum, together with eight known diterpenes (4-11). The structures of compounds (1-11) were elucidated using NMR and MS spectroscopic methods. Compound 7 showed moderate activity against HIV-1 replication in vitro (EC= 1.38 μM). This article is protected by copyright. All rights reserved.