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Terpenes from Euphorbia antiquorum and their anti-HIV activity in vitro.

Terpenes from Euphorbia antiquorum and their anti-HIV activity in vitro.
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Dong M, Chen XQ, Chen CH, Li RT,


Dong M, Chen XQ, Chen CH, Li RT, (click to view)

Dong M, Chen XQ, Chen CH, Li RT,

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Chemistry & biodiversity 2018 03 22() doi 10.1002/cbdv.201700560

Abstract

Three new compounds (1-3), including two euphane type triterpenes, 25,26,27-trinor-3α-hydroxy-24-dimethoxyeuphane (1), and euphane-24β-hydroperoxy-8,25-diene-3β-ol (2), and an ent-atisine diterpene, ent-atisane-3α, 16α, 17-triol (3) were isolated from an acetone extract of the stems of Euphorbia antiquorum, together with eight known diterpenes (4-11). The structures of compounds (1-11) were elucidated using NMR and MS spectroscopic methods. Compound 7 showed moderate activity against HIV-1 replication in vitro (EC= 1.38 μM). This article is protected by copyright. All rights reserved.

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