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The Cerebrovascular-Chronic Kidney Disease Connection: Perspectives and Mechanisms.

The Cerebrovascular-Chronic Kidney Disease Connection: Perspectives and Mechanisms.
Author Information (click to view)

Lau WL, Huisa BN, Fisher M,


Lau WL, Huisa BN, Fisher M, (click to view)

Lau WL, Huisa BN, Fisher M,

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Translational stroke research 2016 09 148(1) 67-76 doi 10.1007/s12975-016-0499-x
Abstract

Chronic kidney disease (CKD) is an independent risk factor for the development of cerebrovascular disease, particularly small vessel disease which can manifest in a variety of phenotypes ranging from lacunes to microbleeds. Small vessel disease likely contributes to cognitive dysfunction in the CKD population. Non-traditional risk factors for vascular injury in uremia include loss of calcification inhibitors, hyperphosphatemia, increased blood pressure variability, elastinolysis, platelet dysfunction, and chronic inflammation. In this review, we discuss the putative pathways by which these mechanisms may promote cerebrovascular disease and thus increase risk of future stroke in CKD patients.

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