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The COMT-polymorphism is not associated with the incidence of acute kidney injury after cardiac surgery – a prospective cohort study.

The COMT-polymorphism is not associated with the incidence of acute kidney injury after cardiac surgery – a prospective cohort study.
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Oezkur M, Magyar A, Thomas P, Reif A, Störk S, Heuschmann PU, Leyh RG, Wagner M,


Oezkur M, Magyar A, Thomas P, Reif A, Störk S, Heuschmann PU, Leyh RG, Wagner M, (click to view)

Oezkur M, Magyar A, Thomas P, Reif A, Störk S, Heuschmann PU, Leyh RG, Wagner M,

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BMC nephrology 2018 02 0919(1) 34 doi 10.1186/s12882-018-0820-x
Abstract
BACKGROUND
The Catechol-O-methyltransferase (COMT) represents the key enzyme in catecholamine degradation. Recent studies suggest that the COMT rs4680 polymorphism is associated with the response to endogenous and exogenous catecholamines. There are, however, conflicting data regarding the COMT Met/Met phenotype being associated with an increased risk of acute kidney injury (AKI) after cardiac surgery. The aim of the current study is to prospectively investigate the impact of the COMT rs4680 polymorphism on the incidence of AKI in patients undergoing cardiac surgery.

METHODS
In this prospective single center cohort study consecutive patients hospitalized for elective cardiac surgery including cardiopulmonary-bypass (CPB) were screened for participation. Demographic clinical data, blood, urine and tissue samples were collected at predefined time points throughout the clinical stay. AKI was defined according to recent recommendations of the Kidney Disease Improving Global Outcome (KDIGO) group. Genetic analysis was performed after patient enrolment was completed.

RESULTS
Between April and December 2014, 150 patients were recruited. The COMT genotypes were distributed as follows: Val/Met 48.7%, Met/Met 29.3%, Val/Val 21.3%. No significant differences were found for demography, comorbidities, or operative strategy according to the underlying COMT genotype. AKI occurred in 35 patients (23.5%) of the total cohort, and no differences were evident between the COMT genotypes (20.5% Met/Met, 24.7% Val/Met, 25.0% Val/Val, p = 0.66). There were also no differences in the post-operative period, including ICU or in-hospital stay.

CONCLUSIONS
We did not find statistically significant variations in the risk for postoperative AKI, length of ICU or in-hospital stay according to the underlying COMT genotype.

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