Advertisement

 

 

The current status, challenges, and future developments of new tuberculosis vaccines.

The current status, challenges, and future developments of new tuberculosis vaccines.
Author Information (click to view)

Gong W, Liang Y, Wu X,


Gong W, Liang Y, Wu X, (click to view)

Gong W, Liang Y, Wu X,

Advertisement

Human vaccines & immunotherapeutics 2018 03 30() 1-96 doi 10.1080/21645515.2018.1458806

Abstract

Mycobacterium tuberculosis complex causes tuberculosis (TB), one of the top 10 causes of death worldwide. TB results in more fatalities than multi-drug resistant (MDR) HIV strain related coinfection. Vaccines play a key role in the prevention and control of infectious diseases. Unfortunately, the only licensed preventive vaccine against TB, bacilli Calmette-Guérin (BCG), is ineffective for prevention of pulmonary TB in adults. Therefore, it is very important to develop novel vaccines for TB prevention and control. This literature review provides an overview of the innate and adaptive immune response during M. tuberculosis infection, and presents current developments and challenges to novel TB vaccines. A comprehensive understanding of vaccines in preclinical and clinical studies provides extensive insight for the development of safer and more efficient vaccines, and may inspire new ideas for TB prevention and treatment.

Submit a Comment

Your email address will not be published. Required fields are marked *

4 × one =

[ HIDE/SHOW ]