HDMs are the significant aeroallergens in patients with rhinitis and asthma in China. However, the molecular sensitization of HDM is varied in different regions.
Researchers conducted this study to investigate the Der p molecular sensitization profile of AR patients in Central China.
A total of 130 patients were included. The overall prevalence of positive serum sIgE was 99.2% for Der p, 98.5% for Der f, 81.5% for ACA s, 83.1% for Blo t, 71.5% for Der p1, 64.6% for Der p2, and 11.5% for Der p10. HDM-AR patients with asthma displayed significantly higher concentrations of sIgE to Der p, Der f, Der p1, and Der p2 than did those without asthma. The prevalence of asthma in HDM-AR patients was higher among the patients sensitized to both Der p1 and Der p2 than those sensitized to only one allergen or non sensitized to Der p1 and Der p2.
The study concluded that Der p has high cross-reactivity with other mite species. Der p1 and Der p2 are the significant components to induce Der p sensitization among AR patients in Central China. Sensitization to Der p1 and Der p2 may be a risk factor for developing asthma in HDM-AR patients.
Reference: https://journals.sagepub.com/doi/full/10.1177/1945892418787116
