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The Differential Effects of HIV and HCV on Bone Micro-Architecture and Fracture risk.

The Differential Effects of HIV and HCV on Bone Micro-Architecture and Fracture risk.
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Bedimo RJ, Adams-Huet B, Poindexter J, Brown G, Farukhi I, Castanon R, Turner D, Moore T, Tebas P, Maalouf NM,


Bedimo RJ, Adams-Huet B, Poindexter J, Brown G, Farukhi I, Castanon R, Turner D, Moore T, Tebas P, Maalouf NM, (click to view)

Bedimo RJ, Adams-Huet B, Poindexter J, Brown G, Farukhi I, Castanon R, Turner D, Moore T, Tebas P, Maalouf NM,

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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2017 11 14() doi 10.1093/cid/cix1011

Abstract
Background
HIV/HCV co-infected subjects have a significantly greater osteoporotic fracture risk than HIV-infected, despite the fact that HIV/HCV co-infection has not been associated with lower bone mineral density (BMD) than HIV or HCV alone. We evaluated if changes in bone microarchitecture , measured by trabecular bone score (TBS) could explain these differences.

Design
We performed a prospective, cross-sectional cohort study of virologically suppressed HIV, untreated HCV, HIV/HCV co-infected and non-infected controls.

Methodology
We enrolled 532 male subjects : 57 HIV/HCV, 174 HIV, 123 HCV and 178 controls. We conducted analysis of covariance comparing BMD and TBS between groups, controlling for age, race, BMI and smoking. We used linear regression to evaluate predictors of BMD and TBS and evaluated the effects of severity of HCV infection and Tenofovir (TDF) use.

Results
Despite both infections being associated with decreased BMD, only HCV, but not HIV was associated with lower TBS score. Also, HIV/HCV co-infected subjects had lower TBS scores than HIV mono-infected, HCV mono-infected and uninfected subjects. Neither the use of TDF, , HCV viremia nor the severity of HCV liver disease were associated with lower TBS.

Conclusions
HCV infection is associated with micro-architectural changes at the lumbar spine as assessed by the low TBS score, suggesting that microstructural abnormalities underlie some of the higher fracture risk in HCV infection. TBS might improve fracture risk prediction in HCV infection.

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