For a study, researchers sought to look at irresistible complexity rates between various prostate biopsy methods with a different number of biopsy centers. All patients from 2 clinics who underwent a prostate biopsy between 2012 and 2019 were identified in this review analysis. These emergency clinics included collaborators with various types of prostate biopsies. Any enrolled irresistible complexity in the first 7 days following the biopsy served as the primary outcome indicator. Optional outcomes included bacteremia, hospitalization, and insurmountable challenges in about 30 days. Information was fitted into a strategic relapse model that accommodated possible confounders to examine the risk of contamination following various prostate biopsy techniques. Altogether, 4,233 prostate biopsies in 3,707 patients were incorporated. After efficient transrectal ultrasound-guided prostate biopsy (TRUSPB; 12±1.4 biopsy cores), 4.0% (2,607) of all patients had irresistible confusion in 7 days post-biopsy. Transperineal magnetic resonance imaging (MRI)- ultrasound combination-directed prostate biopsy (16±3.7 biopsy centers) was related to altogether lower contamination rates than efficient TRUSPB (changed OR: 0.29 [0.09-0.73] 95% [CI]). Transrectal designated MRI-ultrasound combination directed prostate biopsy (3.1±0.8 biopsy centers) and transrectal designated in-bore MRI directed prostate biopsy (2.8±0.8 biopsy centers) likewise showed less irresistible confusions than precise TRUSPB (changed OR: 0.41 [0.12-1.12] 95% CI and 0.68 [0.37-1.20] 95% CI, separately). Transperineal prostate biopsy, or transrectal prostate biopsy with a diminished number of biopsy centers, could bring down the gamble of irresistible complexities.