The purpose of this study was to evaluate the influence of renal and glycemic parameters on choroidal thickness (CT) in patients with diabetes with and without diabetic retinopathy (DR).
This cross-sectional study included patients with and without diabetes. Patients underwent comprehensive ocular examination. CT was obtained using spectral domain optical coherence tomography (SD-OCT) with enhanced depth imaging mode (EDI). Clinical parameters were body mass index (BMI); mean arterial pressure; A1C; fasting plasma glucose (FPG); estimate of glomerular filtration rate (eGFR); and capillary plasma glucose (CPG) a few minutes before EDI-SD-OCT.
The study included 275 participants, of whom 42 with diabetes and no DR, 43 with mild NPDR, 46 with moderate NPDR, 39 with severe NPDR, 24 with PDR, 40 with previous PRP treatment for DR, and 41 subjects without diabetes. The diabetic patients had thinner subfoveal CT than non-diabetic participants (280.5µ ± 83.4 vs 327.1 µ ± 48.8, p < 0.001). After multivariable adjustment, CT was significantly correlated with age, DR stage, and CPG. In patients with mild and moderate NPDR, higher level of CPG was associated with thicker CT. This relationship was not found in patients with PDR.
CPG had the strongest correlation with CT in patients with NPDR (mild, moderate and severe) but not with PDR and PRP PDR patients. Our study suggests that glucose level at the time of the test should be aggregated to other systemic and ocular parameters, such as age and axial length, when studying the choroid using SD-OCT.

© 2020 S. Karger AG, Basel.