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The effect of targeted treatment on people with patellofemoral pain: a pragmatic, randomised controlled feasibility study.

The effect of targeted treatment on people with patellofemoral pain: a pragmatic, randomised controlled feasibility study.
Author Information (click to view)

Drew BT, Conaghan PG, Smith TO, Selfe J, Redmond AC,


Drew BT, Conaghan PG, Smith TO, Selfe J, Redmond AC, (click to view)

Drew BT, Conaghan PG, Smith TO, Selfe J, Redmond AC,

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BMC musculoskeletal disorders 2017 08 0418(1) 338 doi 10.1186/s12891-017-1698-7
Abstract
BACKGROUND
Targeted treatment, matched according to specific clinical criteria e.g. hip muscle weakness, may result in better outcomes for people with patellofemoral pain (PFP). However, to ensure the success of future trials, a number of questions on the feasibility of a targeted treatment need clarification. The aim of the study was to explore the feasibility of matched treatment (MT) compared to usual care (UC) management for a subgroup of people with PFP determined to have hip weakness and to explore the mechanism of effect for hip strengthening.

METHODS
In a pragmatic, randomised controlled feasibility study, 24 participants with PFP (58% female; mean age 29 years) were randomly allocated to receive either MT aimed specifically at hip strengthening, or UC over an eight-week period. The primary outcomes were feasibility outcomes, which included rates of adherence, attrition, eligibility, missing data and treatment efficacy. Secondary outcomes focused on the mechanistic outcomes of the intervention, which included hip kinematics.

RESULTS
Conversion to consent (100%), missing data (0%), attrition rate (8%) and adherence to both treatment and appointments (>90%) were deemed successful endpoints. The analysis of treatment efficacy showed that the MT group reported a greater improvement for the Global Rating of Change Scale (62% vs. 9%) and the Anterior Knee Pain Scale (-5.23 vs. 1.18) but no between-group differences for either average or worst pain. Mechanistic outcomes showed a greatest reduction in peak hip internal rotation angle for the MT group (13.1% vs. -2.7%).

CONCLUSION
This feasibility study indicates that a definitive randomised controlled trial investigating a targeted treatment approach is achievable. Findings suggest the mechanism of effect of hip strengthening may be to influence kinematic changes in hip function in the transverse plane.

TRIAL REGISTRATION
This study was registered retrospectively. ISRCTN74560952 . Registration date: 2017-02-06.

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