Aim To study clinical and anamnestic features and tactics of managing patients with acute myocardial infarction (MI) in groups with different effectiveness of resuscitation procedures.Materials and methods Patients were selected using the “Acute Myocardial Infarction Registry” epidemiological program. 219 cases of acute MI recorded from 2007 through 2017, which required emergency life support, were studied. Two groups were formed based on success of the resuscitation: group 1 consisted of patients with acute MI who survived due to the cardiovascular life support (n=61); group 2 included fatal cases after resuscitation failure (n=158). Quantitative variables were described as median and interquartile range, Ме (Q1; Q3); comparison was performed in two independent samples using the Mann-Whitney test. Qualitative variables were presented as absolute and relative values (n (%)). Statistical significance of differences in nominal properties was determined with contingency tables (Pearson χ2; two-tailed Fisher’s exact test). Critical level of two-tailed significance was set equal to 0.05.Results The groups consisted of severe cases at baseline. The groups were sex- and age-matched. Mean age of patients in groups 1 and 2 was 63.5±13.1 and 60.9±14.8 years, respectively (р=0.2); in both groups, females were considerably older than males. Analysis of preceding drug therapy showed that comparable proportions of patients received antihypertensive and/or anti-ischemic treatment; however, the qualitative composition of the therapies was significantly different in these group. Thus, survived patients more frequently than deceased patients received drugs from vitally important groups, including β-blockers (93 % and 13 %, р<0.001), antiplatelets (97 % and 13 %, р<0.001), statins (84 % and 5 %, р<0.001), and angiotensin-converting enzyme (ACE) inhibitors (90 % and 8 %, р<0.001). In additions. success of resuscitation procedures was interrelated with the clinical picture. Thus, in atypical MI, the rate of fatal outcomes was higher (89 % and 56.5 %, р<0.001) despite the life support.Conclusion The patients who survived due to resuscitation procedures more frequently had a history of adequate drug therapy for ischemic heart disease and arterial hypertension with β-blockers, ACE inhibitors, antiplatelets, and statins. In this group, MI mostly had a clinical picture of a prolonged anginal attack. The long-term prediction for survivors after successful resuscitation presently remains important and requires further study.