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The efficacy and safety of valsartan and combination of valsartan and hydrochlorothiazide in the treatment of patients with mild to moderate arterial hypertension…

The efficacy and safety of valsartan and combination of valsartan and hydrochlorothiazide in the treatment of patients with mild to moderate arterial hypertension…
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Accetto R, Widimsky J, Vincelj J, Sirenko Y, Yevgenyevna IC, Barbic Zagar B,


Accetto R, Widimsky J, Vincelj J, Sirenko Y, Yevgenyevna IC, Barbic Zagar B, (click to view)

Accetto R, Widimsky J, Vincelj J, Sirenko Y, Yevgenyevna IC, Barbic Zagar B,

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Kardiologia polska 2017 12 01() doi 10.5603/KP.a2017.0240
Abstract
BACKGROUND AND AIM
The aim of the study was to establish the effect of valsartan and combination of valsartan and hydrochlorotiazide (HCTZ) in a wide population of patients with mild to moderate arterial hypertension on pulse wave velocity (PWV) and central blood pressure (CBP).

METHODS
International, multicenter, open labelled, prospective trial. After one week of washout in previously treated patients, the patients were treated for 16 weeks according to the protocol. Naïve patients received the treatment immediately. During the active treatment, 4 visits were planned for each patient to obtain data for the primary and secondary efficacy. At the beginning and at the end of the study PWV and CBP were performed with the central arterial pressure waveform analysis (SphygmoCor®, Atcor Medical). This study is registered withclinicaltrialsregister.eu, EudraCT number2012-005129-57.

RESULTS
The results of the present Victory trial showed that valsartan and combination of valsartan and HCTZ effectively reduced the brachial BP in patients with mild to moderate arterial hypertension as well as PWV, augmentation index (Aix, although not statistically significant), central systolic blood pressure (CSBP) and central diastolic blood pressure (CDBP).

CONCLUSIONS
Valsartan and valsartan/HCTZ improve arterial stiffness in patients with mild to moderate hypertension.

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