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The endothelial αENaC contributes to vascular endothelial function in vivo.

The endothelial αENaC contributes to vascular endothelial function in vivo.
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Tarjus A, Maase M, Jeggle P, Martinez-Martinez E, Fassot C, Loufrani L, Henrion D, Hansen PBL, Kusche-Vihrog K, Jaisser F,


Tarjus A, Maase M, Jeggle P, Martinez-Martinez E, Fassot C, Loufrani L, Henrion D, Hansen PBL, Kusche-Vihrog K, Jaisser F, (click to view)

Tarjus A, Maase M, Jeggle P, Martinez-Martinez E, Fassot C, Loufrani L, Henrion D, Hansen PBL, Kusche-Vihrog K, Jaisser F,

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PloS one 2017 09 2612(9) e0185319 doi 10.1371/journal.pone.0185319
Abstract

The Epithelial Sodium Channel (ENaC) is a key player in renal sodium homeostasis. The expression of α β γ ENaC subunits has also been described in the endothelium and vascular smooth muscle, suggesting a role in vascular function. We recently demonstrated that endothelial ENaC is involved in aldosterone-modulated endothelial stiffness. Here we explore the functional role of the endothelial αENaC subunit in vascular function in vivo. Compared to littermates, mice with conditional αENaC subunit gene inactivation in the endothelium only (endo-αENaC Knock Out mice) had no difference in their physiological parameters such as systolic blood pressure or heart rate. Acute and long-term renal Na+ handlings were not affected, indicating that endothelial αENaC subunit is not involved in renal sodium balance. Pharmacological inhibition of ENaC with benzamil blunted acetylcholine-induced nitric oxide production in mesenteric arteries from wild type mice but not in endo-αENaC KO mice, suggesting a critical role of endothelial ENaC in agonist-induced nitric oxide production. In endo-αENaC KO mice, compensatory mechanisms occurred and steady state vascular function was not altered except for flow-mediated dilation. Our data suggest that endothelial αENaC contributes to vascular endothelial function in vivo.

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