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The Epidemic History of HIV-1 CRF07_BC in Hetian Prefecture and the Role of It on HIV Spreading in China.

The Epidemic History of HIV-1 CRF07_BC in Hetian Prefecture and the Role of It on HIV Spreading in China.
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Wu J, Guo H, Zhang J, Liu X, Ayoupu A, Shen Y, Miao L, Tang J, Lei Y, Su B,


Wu J, Guo H, Zhang J, Liu X, Ayoupu A, Shen Y, Miao L, Tang J, Lei Y, Su B, (click to view)

Wu J, Guo H, Zhang J, Liu X, Ayoupu A, Shen Y, Miao L, Tang J, Lei Y, Su B,

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AIDS research and human retroviruses 2017 02 13() doi 10.1089/AID.2016.0214

Abstract

CRF07_BC is one of the most prevalent HIV-1 strains in China, and Xinjiang Uygur Autonomous Region has ever been considered to be a second epidemic center after Yunnan Province in previous studies. Here we use HIV-1 pol gene sequences identified from Hetian Prefecture located in Xinjiang Autonomous Region to reconstruct the epidemic history of HIV CRF07_BC strain circulating in this region. We found that CRF07_BC is the predominant HIV-1 form in Hetian Prefecture, and the estimated tMRCA analysis shows that there is no enough evidence supporting Xinjiang Autonomous Region as a second epidemic center of spreading HIV-1. It may imply that every city may be only a point among the HIV spreading network because of the frequent migration of population in the whole country nowadays.

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