The purpose of this study was to assess mothers’ knowledge and attitudes regarding the human papillomavirus (HPV) vaccination among 8th graders in Israel, as well as to identify the characteristics related with maternal consent to the HPV vaccine. During the 2016–17 school year, researchers performed a cross-sectional survey among mothers of eighth-grade kids in 27 schools in Haifa and the northern regions of Israel. A systematic telephone questionnaire was used to collect data. The questionnaire was completed by 313 moms. The average knowledge level was poor. Knowledge level was shown to be positively related to Jewish nationality, secular religious activity, and higher education. The mean attitude score was low-moderate. Arab nationality was connected with a higher attitude score. There was no significant relationship observed between knowledge level and attitudes. According to multivariate analysis, mothers’ willingness to receive the HPV vaccine was related to their knowledge level, attitude level, and country.

The degree of information and attitudes about the HPV vaccine were found to be inadequate, with racial differences between Arabs and Jews. When compared to Arab moms, Jewish mothers with more information or fewer favorable views were less likely to consent to the vaccination. These findings may aid in the adaptation of programs to the various Israeli sectors in order to enhance the rates of HPV vaccination reception among teenagers.