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The functions and unique features of long intergenic non-coding RNA.

The functions and unique features of long intergenic non-coding RNA.
Author Information (click to view)

Ransohoff JD, Wei Y, Khavari PA,


Ransohoff JD, Wei Y, Khavari PA, (click to view)

Ransohoff JD, Wei Y, Khavari PA,

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Nature reviews. Molecular cell biology 2017 11 15() doi 10.1038/nrm.2017.104

Abstract

Long intergenic non-coding RNA (lincRNA) genes have diverse features that distinguish them from mRNA-encoding genes and exercise functions such as remodelling chromatin and genome architecture, RNA stabilization and transcription regulation, including enhancer-associated activity. Some genes currently annotated as encoding lincRNAs include small open reading frames (smORFs) and encode functional peptides and thus may be more properly classified as coding RNAs. lincRNAs may broadly serve to fine-tune the expression of neighbouring genes with remarkable tissue specificity through a diversity of mechanisms, highlighting our rapidly evolving understanding of the non-coding genome.

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