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The HIV-1 Glycan Shield: Strategically Placed Kinks in the Armor Improve Antigen Design.

The HIV-1 Glycan Shield: Strategically Placed Kinks in the Armor Improve Antigen Design.
Author Information (click to view)

Karsten CB, Alter G,


Karsten CB, Alter G, (click to view)

Karsten CB, Alter G,

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Cell reports 19(4) 669-670 pii 10.1016/j.celrep.2017.04.033

Abstract

Dense glycosylation on the HIV-1 envelope glycoprotein hampers the induction of broadly neutralizing antibodies against HIV-1. Zhou et al. remove key glycans to unmask sites of vulnerability and enable the induction of neutralizing antibodies.

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