Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) latently infects approximately one-fourth of the world’s population. The immune mechanisms that govern progression from latent (LTBI) to active pulmonary TB (PTB) remain poorly defined. Experimentally Mtb-infected non-human primates (NHP) mirror the disease observed in humans and recapitulate both PTB and LTBI. We characterized the lung immune landscape in NHPs with LTBI and PTB using high-throughput technologies. Three defining features of PTB in macaque lungs include the influx of plasmacytoid dendritic cells (pDCs), an Interferon (IFN)-responsive macrophage population, and activated T cell responses. In contrast, a CD27 Natural killer (NK) cell subset accumulated in the lungs of LTBI macaques. This NK cell population was also detected in the circulation of LTBI individuals. This comprehensive analysis of the lung immune landscape will improve the understanding of TB immunopathogenesis, providing potential targets for therapies and vaccines for TB control.Copyright © 2020 Elsevier Inc. All rights reserved.
About The Expert
Ekaterina Esaulova
Shibali Das
Dhiraj Kumar Singh
Jose Alberto Choreño-Parra
Amanda Swain
Laura Arthur
Javier Rangel-Moreno
Mushtaq Ahmed
Bindu Singh
Ananya Gupta
Luis Alejandro Fernández-López
Maria de la Luz Garcia-Hernandez
Allison Bucsan
Chivonne Moodley
Smriti Mehra
Ethel García-Latorre
Joaquin Zuniga
Jeffrey Atkinson
Deepak Kaushal
Maxim N Artyomov
Shabaana A Khader
References
PubMed