Advertisement

 

 

The long-term prognostic value of highly sensitive cardiac troponin I in patients with acute pulmonary embolism.

The long-term prognostic value of highly sensitive cardiac troponin I in patients with acute pulmonary embolism.
Author Information (click to view)

Lee Chuy K, Hakemi EU, Alyousef T, Dang G, Doukky R,


Lee Chuy K, Hakemi EU, Alyousef T, Dang G, Doukky R, (click to view)

Lee Chuy K, Hakemi EU, Alyousef T, Dang G, Doukky R,

Advertisement
Share on FacebookTweet about this on TwitterShare on LinkedIn

Clinical cardiology 2017 12 15() doi 10.1002/clc.22823
Abstract
BACKGROUND
In patients with acute pulmonary embolism (PE), detectable levels of cardiac troponin I (cTnI) using a highly sensitive assay have been associated with increased in-hospital mortality. We sought to investigate the impact of detectable cTnI on long-term survival following acute PE.

HYPOTHESIS
Detectable cTnI levels in patients presenting with acute PE predict increased long-term mortality following hospital discharge.

METHODS
In a retrospective cohort study, we analyzed consecutive patients with confirmed acute PE and cTnI assay available from the index hospitalization. The detectable cTnI level was ≥0.012 ng/mL. Patients were classified into low and high clinical risk groups according to the Pulmonary Embolism Severity Index (PESI) at presentation. Subjects were followed for all-cause mortality subsequent to hospital discharge using chart review and Social Security Death Index.

RESULTS
A cohort of 289 acute PE patients (mean age 56 years, 51% men), of whom 152 (53%) had a detectable cTnI, was followed for a mean of 3.1 ± 1.8 years after hospital discharge. A total of 71 deaths were observed; 44 (29%) and 27 (20%) in the detectable and undetectable cTnI groups, respectively (P = 0.05). Detectable cTnI was predictive of long-term survival among low-risk (P = 0.009) but not high-risk patients (P = 0.78) who had high mortality rates irrespective of cTnI status.

CONCLUSIONS
In patients with acute PE, detectable cTnI is predictive of long-term mortality, particularly among patients who were identified as low risk according to PESI score.

Submit a Comment

Your email address will not be published. Required fields are marked *

twelve − eleven =

[ HIDE/SHOW ]