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The metabolomics and lipidomics window into thyroid cancer research.

The metabolomics and lipidomics window into thyroid cancer research.
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Farrokhi Yekta R, Rezaie Tavirani M, Arefi Oskouie A, Mohajeri-Tehrani MR, Soroush AR,


Farrokhi Yekta R, Rezaie Tavirani M, Arefi Oskouie A, Mohajeri-Tehrani MR, Soroush AR, (click to view)

Farrokhi Yekta R, Rezaie Tavirani M, Arefi Oskouie A, Mohajeri-Tehrani MR, Soroush AR,

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Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2016 11 1522(7) 595-603 doi 10.1080/1354750X.2016.1256429

Abstract
CONTEXT
Thyroid carcinoma is the most common endocrine system malignancy with a fast rising incidence in the last decade for unknown reasons. Fine needle aspiration (FNA) biopsy, the gold standard in thyroid cancer (TC) screening has still its own challenges and in some cases needs a proceeding surgery.

OBJECTIVE
This review highlights the role of the two most recent "omics" approaches, "metabolomics" and "lipidomics", in the field of TC research.

METHODS
All the previous studies have been extracted from the literature and major concepts were detailed in the field of TC metabolomics and lipidomics.

RESULTS
Metabolomics and lipidomics, have potential in finding biomarkers related to thyroid carcinoma. Among the previous studies, the most important introduced altered tissue metabolites and lipids included glucose and galactose, lactate, Scyllo- and Myo inositol, hypoxanthine, citrate, cholesterol and choline.

CONCLUSION
Metabolomics methods have been widely used in the field of biomarker discovery in TC and attempts are still in progress to use these methods to find a reliable biomarker panel besides current diagnostic tools.

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