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The Mozart study: a relation between dynamic hyperinflation and physical activity in patients with chronic obstructive pulmonary disease?

The Mozart study: a relation between dynamic hyperinflation and physical activity in patients with chronic obstructive pulmonary disease?
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van Leuteren RW, Dijkhuis S, de Jongh FH, van der Valk PD, Tabak M, Brusse-Keizer MG,


van Leuteren RW, Dijkhuis S, de Jongh FH, van der Valk PD, Tabak M, Brusse-Keizer MG, (click to view)

van Leuteren RW, Dijkhuis S, de Jongh FH, van der Valk PD, Tabak M, Brusse-Keizer MG,

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Clinical physiology and functional imaging 2017 04 12() doi 10.1111/cpf.12430
Abstract
BACKGROUND
Many patients with chronic obstructive pulmonary disease (COPD) experience dyspnoea during exercise, resulting in a reduction of physical activity (PA). Dynamic hyperinflation (DH) is seen as a major cause of dyspnoea in COPD.

OBJECTIVE
The objective of the current study was to investigate the relationship between DH, in terms of the amount of DH and the development and recovery rate of DH in patients with COPD, and PA.

METHODS
Thirty-five patients with stable COPD were included from an outpatient clinic (14 GOLD II and 21 GOLD III, median age 65). PA was assessed using an accelerometer. Subjects underwent metronome-paced tachypnoea (MPT) to induce DH. To quantify the amount of DH during MPT, a decrease in inspiratory capacity (IC) or a change in IC as percentage of total lung capacity was used.

RESULTS
No significant correlations were found between the parameters describing DH and PA. Secondary correlation analyses showed a negative correlation between static hyperinflation (SH) and PA (r = -0·39; P = 0·02). The pattern of breathing during MPT and the test itself showed high interpatient variability.

CONCLUSIONS
The absence of a significant correlation between DH and PA is contrary to previous studies. SH did show a correlation with PA. The variety in results and the technical difficulties in execution of the measurements ask for a new, more reliable, method to detect DH and investigate its relation with PA in patients with COPD.

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