Mites are the most prevalent allergens and the most important cause of breathing allergies worldwide. A deep discussion will be held on the life cycle, the allergenic components, biological activity and immunogenicity. It is now well-known that mite allergens can stimulate the innate immune system via several receptors, e.g. TLRs and PARs. Followed by type 2, cytokine polarisation in susceptible individuals, activation of cells in the airway mucosa is followed by This intricate network plays a key role in the promotion of Th2 differentiation.

The following is a complete review of all known mite allergens, including their presence in dust mites, composition, biological activities and the destiny-related binding receptors.