In recent times, the first-ever study was conducted in the United Kingdom for understanding the effects of definitive chemoradiotherapy in oesophageal cancer. Therefore, this treatment is described as a standard treatment for curing the people who have been diagnosed with this deadly disease. However, there are certain limitations of using this product, and hence what matters the most is that this treatment is linked with toxicity and hence, the treatment is less effective for the elderly population and the frail population. For conducting this research, nearly 9 radiotherapies across the centers in the United Kingdom were studied. The studies aimed at measuring the survival rate of the people who were already suffering from diseases like esophagus cancer, when such people were diagnosed with the recommended radiation dose of 50 Gy in 25 daily fractions. Therefore, when the results came out,, it was discovered that the possibility of survival decreased with the increasing age. The rate of survival post this treatment was only 18 percent for the people who were above 80 years of age. Therefore, such therapies are well tolerated by young people as compared to the elderly.

Ref art: https://www.clinicaloncologyonline.net/article/S0936-6555(19)30439-X/fulltext